Aprea Therapeutics is developing our lead program, APR-246, a novel reactivator of dysfunctional p53 that is positioned to be first-in-class. The safety, tolerability and activity of APR-246 have been established, including the potential for synergistic combination therapy with chemotherapy and immunotherapy agents.
We are currently enrolling a Phase II trial for APR-246 in platinum-sensitive and partially platinum-sensitive high-grade serous ovarian cancer (HGSOC). Phase Ib trials for platinum-resistant HGSOC, esophageal cancer, and myelodysplastic syndrome will be initiated in 2017. We are conducting preclinical evaluation of other cancer indications and additional Phase Ib studies are planned.
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