DNA Damage Response Modulators
Our pipeline of DNA Damage Response modulators includes novel inhibitors of ATR and WEE1.
ATRN-119: Novel macrocyclic ATR inhibitor
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Phase 1 clinical trial commenced 1Q, 2023
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Unique biomarkers identified for optimized patient selection
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Differentiated, macrocyclic molecular structure
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Potential for lower hematological toxicity versus other ATR inhibitors
ATRN-W1051: Novel WEE1 inhibitor
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Structurally differentiated from other WEE1 inhibitors
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Excellent selectivity for WEE1 versus PLK1/2/3, potentially limiting off-target toxicity
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Nanomolar anti-proliferative activity against multiple cancer cell lines
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Promising anti-tumor activity in tumor model
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Potential for improved PK properties versus other WEE1 inhibitors
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IND filing anticipated 4Q, 2023
DDR PIPELINE
program / target
molecule
discovery
optimization
IND-enabling
phase one
ATR
ATR
WEE1
Novel DDR Target
ATRN-119
Undisclosed
ATRN-W1051
Undisclosed